[HTML][HTML] The phosphotyrosine binding-like domain of talin activates integrins
DA Calderwood, B Yan, JM de Pereda… - Journal of Biological …, 2002 - ASBMB
Cellular regulation of the ligand binding affinity of integrin adhesion receptors (integrin
activation) depends on the integrin β cytoplasmic domains (tails). The head domain of talin
binds to several integrin β tails and activates integrins. This head domain contains a
predicted FERM domain composed of three subdomains (F1, F2, and F3). An integrin-
activating talin fragment was predicted to contain the F2 and F3 subdomains. Both isolated
subdomains bound specifically to the integrin β 3 tail. However, talin F3 bound the β 3 tail …
activation) depends on the integrin β cytoplasmic domains (tails). The head domain of talin
binds to several integrin β tails and activates integrins. This head domain contains a
predicted FERM domain composed of three subdomains (F1, F2, and F3). An integrin-
activating talin fragment was predicted to contain the F2 and F3 subdomains. Both isolated
subdomains bound specifically to the integrin β 3 tail. However, talin F3 bound the β 3 tail …