[HTML][HTML] ICln, a novel integrin αIIbβ3-associated protein, functionally regulates platelet activation
A critical role for the conserved α-integrin cytoplasmic motif, KVGFFKR, is recognized in the
regulation of activation of the platelet integrin α IIb β 3. To understand the molecular
mechanisms of this regulation, we sought to determine the nature of the protein interactions
with this cytoplasmic motif. We used a tagged synthetic peptide, biotin-KVGFFKR, to probe a
high density protein expression array (37,200 recombinant human proteins) for high affinity
interactions. A number of potential integrin-binding proteins were identified. One such …
regulation of activation of the platelet integrin α IIb β 3. To understand the molecular
mechanisms of this regulation, we sought to determine the nature of the protein interactions
with this cytoplasmic motif. We used a tagged synthetic peptide, biotin-KVGFFKR, to probe a
high density protein expression array (37,200 recombinant human proteins) for high affinity
interactions. A number of potential integrin-binding proteins were identified. One such …