[HTML][HTML] Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin α subunits that plays a crucial role in …
A Kato, N Kawamata, K Tamayose, M Egashira… - Journal of Biological …, 2002 - ASBMB
Modification of the cytoplasmic tails of the integrin α IIb β 3 plays an important role in the
signal transduction in platelets. We searched for proteins that bind to the α IIb cytoplasmic
tail using the yeast two-hybrid assay with a cDNA library of the megakaryocyte-derived cell
line and identified a protein, ancient ubiquitous protein 1 (Aup1), that is ubiquitously
expressed in human cells. Observation of UT7/TPO cells expressing a red fluorescent
protein-tagged Aup1 indicated its localization in the cytoplasm. Immunoprecipitation of …
signal transduction in platelets. We searched for proteins that bind to the α IIb cytoplasmic
tail using the yeast two-hybrid assay with a cDNA library of the megakaryocyte-derived cell
line and identified a protein, ancient ubiquitous protein 1 (Aup1), that is ubiquitously
expressed in human cells. Observation of UT7/TPO cells expressing a red fluorescent
protein-tagged Aup1 indicated its localization in the cytoplasm. Immunoprecipitation of …