[HTML][HTML] Thrombopoietin signal transduction requires functional JAK2, not TYK2
JG Drachman, KM Millett, K Kaushansky - Journal of Biological Chemistry, 1999 - ASBMB
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by
members of the cytokine receptor superfamily. In response to ligand-receptor interaction,
these nonreceptor tyrosine kinases are rapidly phosphorylated and activated, triggering
tyrosine phosphorylation and activation of downstream signaling intermediates. Upon
binding to its receptor, the product of the proto-oncogene c-mpl, thrombopoietin (TPO)
activates both JAK2 and TYK2 in multiple cell lines as well as megakaryocytes and platelets …
members of the cytokine receptor superfamily. In response to ligand-receptor interaction,
these nonreceptor tyrosine kinases are rapidly phosphorylated and activated, triggering
tyrosine phosphorylation and activation of downstream signaling intermediates. Upon
binding to its receptor, the product of the proto-oncogene c-mpl, thrombopoietin (TPO)
activates both JAK2 and TYK2 in multiple cell lines as well as megakaryocytes and platelets …
