[HTML][HTML] MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin …
GA Millot, F Feger, L Garçon, W Vainchenker… - Experimental …, 2002 - Elsevier
OBJECTIVE: Interaction of thrombopoietin (TPO) with its receptor c-Mpl is responsible for the
formation of megakaryocytes and platelets. In humans, there are two major c-mpl molecules,
MplP and MplK, which are generated by alternative splicing. In contrast to MplP, MplK has
none of the intracellular sequences required for typical signal transduction but instead has a
unique 27 amino acid sequence that is coded by intron 10. We tested to determine if MplK
exerts a negative effect on TPO Mpl signal transduction by interfering with the normal …
formation of megakaryocytes and platelets. In humans, there are two major c-mpl molecules,
MplP and MplK, which are generated by alternative splicing. In contrast to MplP, MplK has
none of the intracellular sequences required for typical signal transduction but instead has a
unique 27 amino acid sequence that is coded by intron 10. We tested to determine if MplK
exerts a negative effect on TPO Mpl signal transduction by interfering with the normal …
