Mutation and expression of the p53 gene in human malignant melanoma
AP Albino, MJ Vidal, NS McNutt, CR Shea… - Melanoma …, 1994 - journals.lww.com
Derangement of the p53 tumor suppressor gene has been implicated in the aetiology of a
wide range of human neoplasias. We have previously determined that overexpression and
mutation of the p53 gene in cultured metastatic melanomas is low (11%). However, two
recent immunohistochemical studies have reported that> 85% of malignant melanoma
specimens overexpress mutated p53 protein. In an effort to resolve this contradiction in the
published literature, we have re-evaluated a range of cultured and non-cultured melanocytic …
wide range of human neoplasias. We have previously determined that overexpression and
mutation of the p53 gene in cultured metastatic melanomas is low (11%). However, two
recent immunohistochemical studies have reported that> 85% of malignant melanoma
specimens overexpress mutated p53 protein. In an effort to resolve this contradiction in the
published literature, we have re-evaluated a range of cultured and non-cultured melanocytic …
