Tissue fibrosis can lead to significant organ dysfunction and resulting patient morbidity and
mortality. Unfortunately, the therapeutic repertoire is currently limited, nonspecific, and
largely ineffective. While the pathogenesis is incompletely understood, evidence is
accumulating that immune and cytokine mediated mechanisms are critical. In this review,
data will be provided to support the role of Type 2 cytokines in the pathogenesis of fibrosis.
The importance of the role of the pro-fibrogenic cytokine TGF-β and CD40–CD40 ligand …