Nucleotide receptors in the nervous system: an abundant component using diverse transduction mechanisms
EA Barnard, J Simon, TE Webb - Molecular neurobiology, 1997 - Springer
EA Barnard, J Simon, TE Webb
Molecular neurobiology, 1997•SpringerExtracellular nucleotides achieve their role as cell-to-cell communicators by acting at cell
surface transmembrane receptors—the P2 receptors. Before molecular cloning led to the
isolation of any P2-receptor sequence, a small number of receptor types had been proposed
on the basis of pharmacological evidence. The application of molecular biology to this field
of receptor research has indicated that a great underestimation of the number of receptor
subtypes and of their abundance had occurred. There are now known to be seven …
surface transmembrane receptors—the P2 receptors. Before molecular cloning led to the
isolation of any P2-receptor sequence, a small number of receptor types had been proposed
on the basis of pharmacological evidence. The application of molecular biology to this field
of receptor research has indicated that a great underestimation of the number of receptor
subtypes and of their abundance had occurred. There are now known to be seven …
Abstract
Extracellular nucleotides achieve their role as cell-to-cell communicators by acting at cell surface transmembrane receptors—the P2 receptors. Before molecular cloning led to the isolation of any P2-receptor sequence, a small number of receptor types had been proposed on the basis of pharmacological evidence. The application of molecular biology to this field of receptor research has indicated that a great underestimation of the number of receptor subtypes and of their abundance had occurred. There are now known to be seven characterized P2Y (G protein linked) receptors and the same number again of P2X receptors of the transmitter-gated ion channel type. In this review, we discuss the properties of these cloned receptors, their distribution within the nervous system, and their methods of signal transduction.
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