Poly (ADP-ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass
BACKGROUND: Poly (ADP-ribose) polymerase activation has been shown to contribute to
the pathogenesis of myocardial ischemia-reperfusion injury. We hypothesized that a novel
poly (ADP-ribose) polymerase inhibitor, INO-1001, provides myocardial protection and
improves cardiac function after regional ischemia and cardioplegia-cardiopulmonary bypass
(CPB). STUDY DESIGN: Pigs were subjected to 30 minutes of regional ischemia by distal
left anterior descending coronary artery ligation followed by CPB (60 minutes) with …
the pathogenesis of myocardial ischemia-reperfusion injury. We hypothesized that a novel
poly (ADP-ribose) polymerase inhibitor, INO-1001, provides myocardial protection and
improves cardiac function after regional ischemia and cardioplegia-cardiopulmonary bypass
(CPB). STUDY DESIGN: Pigs were subjected to 30 minutes of regional ischemia by distal
left anterior descending coronary artery ligation followed by CPB (60 minutes) with …