Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou
J Liu, Z Zhuang, Y Tan, Z Shi, X Li, X Yang… - Chinese medical …, 1984 - mednexus.org
J Liu, Z Zhuang, Y Tan, Z Shi, X Li, X Yang, J Wu, B Chen, J Zhang, J Qin, D Kong
Chinese medical journal, 1984•mednexus.orgTwo of 3 6th-month fetuses of an endemic cretinism region showed that the brain was
decreased in weight and size and exhibited an increased number of nerve cells per unit of
brain volume. 2 of 3 8th-month-old fetuses from the same region showed the brain not only
decreased in weight and size, but also had such histologic characteristics as increased
number of nerve cells per unit of brain volume, increased percentage of undifferentiated
neuroblasts, increased number of heterotopic nerve cells and decreased number of …
decreased in weight and size and exhibited an increased number of nerve cells per unit of
brain volume. 2 of 3 8th-month-old fetuses from the same region showed the brain not only
decreased in weight and size, but also had such histologic characteristics as increased
number of nerve cells per unit of brain volume, increased percentage of undifferentiated
neuroblasts, increased number of heterotopic nerve cells and decreased number of …
Two of 3 6th-month fetuses of an endemic cretinism region showed that the brain was decreased in weight and size and exhibited an increased number of nerve cells per unit of brain volume. 2 of 3 8th-month-old fetuses from the same region showed the brain not only decreased in weight and size, but also had such histologic characteristics as increased number of nerve cells per unit of brain volume, increased percentage of undifferentiated neuroblasts, increased number of heterotopic nerve cells and decreased number of astrocytes per unit of brain volume. This investigation seems to suggest that cerebral cortex retarded development of fetuses in endemic region may be due to prenatal iodine deficiency and/or hypothyroidism, which is substantiated by low fetal serum thyroxine levels.
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