Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?
B Lelongt, B Legallicier, R Piedagnel… - Current opinion in …, 2001 - journals.lww.com
B Lelongt, B Legallicier, R Piedagnel, PM Ronco
Current opinion in nephrology and hypertension, 2001•journals.lww.comAbstract Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell
invasion and in embryonic development and organogenesis. A growing number of reports
suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule
physiology and glomerular pathophysiology. This editorial will focus on recent controversial
data, especially those obtained from studies on MMP-9-deficient mice, which shed new light
on the functions of gelatinases in normal and diseased kidneys.
invasion and in embryonic development and organogenesis. A growing number of reports
suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule
physiology and glomerular pathophysiology. This editorial will focus on recent controversial
data, especially those obtained from studies on MMP-9-deficient mice, which shed new light
on the functions of gelatinases in normal and diseased kidneys.
Abstract
Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell invasion and in embryonic development and organogenesis. A growing number of reports suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule physiology and glomerular pathophysiology. This editorial will focus on recent controversial data, especially those obtained from studies on MMP-9-deficient mice, which shed new light on the functions of gelatinases in normal and diseased kidneys.
Lippincott Williams & Wilkins