Effects of transforming growth factor-β1 on renal extracellular matrix components and their regulating proteins
JA Douthwaite, TS Johnson, JL Haylor… - Journal of the …, 1999 - journals.lww.com
Transforming growth factor-β1 (TGF-β1) is widely regarded as a potent fibrogenic renal
growth factor. In cell culture, TGF-β1 has been shown to increase various extracellular matrix
(ECM) proteins and tissue inhibitors of metalloproteinases (TIMP), while decreasing matrix
metalloproteinases (MMP), providing the optimum environment for progressive ECM
accumulation. This study, which uses the isolated perfused rat kidney (IPRK), describes for
the first time in a whole kidney preparation the action of TGF-β1 on factors associated with …
growth factor. In cell culture, TGF-β1 has been shown to increase various extracellular matrix
(ECM) proteins and tissue inhibitors of metalloproteinases (TIMP), while decreasing matrix
metalloproteinases (MMP), providing the optimum environment for progressive ECM
accumulation. This study, which uses the isolated perfused rat kidney (IPRK), describes for
the first time in a whole kidney preparation the action of TGF-β1 on factors associated with …